Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.63 |
| ▸ | AR | P10275 | 4/20 | 0.63 |
| ▸ | PGR | P06401 | 4/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | IL5 | P05113 | 1/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352704 | 0.93 | NR3C1 (0.74) | CYP3A4NR3C1ARPGRUSP2 | |
| SCHEMBL10543449 | 0.93 | NR3C1 (0.74) | CYP3A4NR3C1ARPGRUSP2 | |
| SCHEMBL10352327 | 0.93 | NR3C1 (0.74) | CYP3A4NR3C1ARPGRUSP2 | |
| SCHEMBL9114073 | 0.93 | NR3C1 (0.64) | CYP3A4NR3C1ARPGRUSP2 | |
| Rofleponide SCHEMBL23803954 | 0.87 | NR3C1 (0.68) | CYP3A4NR3C1ARPGRHIF1A | |
| Rofleponide SCHEMBL74762 | 0.87 | NR3C1 (0.68) | CYP3A4NR3C1ARPGRHIF1A | |
| Rofleponide SCHEMBL5506220 | 0.87 | NR3C1 (0.68) | CYP3A4NR3C1ARPGRHIF1A | |
| Rofleponide SCHEMBL8505525 | 0.87 | NR3C1 (0.68) | CYP3A4NR3C1ARPGRHIF1A | |
| Rofleponide SCHEMBL7196822 | 0.87 | NR3C1 (0.68) | CYP3A4NR3C1ARPGRHIF1A | |
| SCHEMBL8501453 | 0.87 | NR3C1 (0.55) | CYP3A4NR3C1ARPGRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164636-B1 | A PROCESS FOR THE PREPARATION OF 16,17 ACETALS OF PREGNANE DERIVATIVES AND COMPOUNDS OBTAINED THEREFROM | SICOR Società Italiana Corticosteroidi S.p.A. (IT) | 1990-09-19 | — | — | EP | claimed |
| US-5939409-A | CONDENSATION OF ALDEHYDE WITH STEROIDIOL TO FORM AN ACETAL GROUPS | ASTRA AKTIEBOLAG (SE) | 1999-08-17 | — | — | US | disclosed |
| EP-0570454-B1 | NOVEL STEROIDS | ASTRA AB (SE) | 1999-04-07 | — | — | EP | disclosed |
| US-5888995-A | ANTIINFLAMMATORY AND ANTIALLERGENIC AGENTS; A NOVEL GLUCOCORTICOSTEROID | ASTRA AKTIEBOLAG (SE) | 1999-03-30 | — | — | US | disclosed |
| US-5674861-A | GLUCOCORTICOSTEROIDS FOR LOCAL TREATMENT OF INFLAMMATORY DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-10-07 | — | — | US | disclosed |
| US-5614514-A | Steroid esters | AKTIEBOLAGET ASTRA (SE) | 1997-03-25 | — | — | US | disclosed |
| US-4812591-A | Process for the preparation of bisphenol-bisacrylates | BAYER AKTIENGESELLSCHAFT (DE) | 1989-03-14 | — | — | US | disclosed |
| US-4695625-A | Process for the preparation of 16,17 acetals of pregnane derivatives | SICOR SOCIETA ITALIANA CORTICOSTEROIDI S.P.A. (IT) | 1987-09-22 | — | — | US | disclosed |
| EP-0164636-A2 | A process for the preparation of 16,17 acetals of pregnane derivatives and compounds obtained therefrom | SICOR Società Italiana Corticosteroidi S.p.A. (IT) | 1985-12-18 | — | — | EP | disclosed |