Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373859 | 0.75 | GPR132 (0.53) | CA1CA2 | |
| SCHEMBL30902537 | 0.73 | NOS3 (0.60) | GRIA2 | |
| SCHEMBL7863123 | 0.72 | ITGB3 (0.39) | CA12CA1CA2CA9ITGB3 | |
| SCHEMBL8909236 | 0.72 | CYP1A2 (0.63) | MMP2MMP9 | |
| SCHEMBL7327841 | 0.72 | CYP1A2 (0.63) | MMP2MMP9 | |
| SCHEMBL7349315 | 0.72 | CYP1A2 (0.63) | MMP2MMP9 | |
| SCHEMBL7377643 | 0.72 | F10 (0.46) | ITGB3 | |
| SCHEMBL5418308 | 0.71 | CYP1A2 (0.51) | ADAMTS4GRIA2ITGB3ITGAVMMP2 | |
| SCHEMBL7838300 | 0.71 | ITGB3 (0.51) | ITGB3ITGAV | |
| SCHEMBL8075755 | 0.69 | NOS3 (0.43) | CA12CA1CA2CA9GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |