Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503193 | 0.84 | NR4A1 (0.40) | HTTIDO1ALDH1A1SMN1; SMN2MITF | |
| SCHEMBL8502112 | 0.74 | IDO1 (0.40) | IDO1ALDH1A1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL8502514 | 0.74 | IDO1 (0.40) | IDO1ALDH1A1SMN1; SMN2TP53CYP3A4 | |
| SCHEMBL8502103 | 0.74 | BDKRB1 (0.37) | HTTIDO1ALDH1A1TP53MAPT | |
| SCHEMBL8504761 | 0.73 | IDO1 (0.37) | IDO1ALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL8504853 | 0.73 | KMT2A (0.49) | MAPTHPGDRAB9AKMT2A | |
| SCHEMBL8501896 | 0.68 | NPC1 (0.38) | HTTALDH1A1SMN1; SMN2MITFS1PR4 | |
| SCHEMBL8503700 | 0.68 | POLB (0.43) | HTTIDO1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL8505614 | 0.68 | NLRP3 (0.41) | HTTIDO1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL8502482 | 0.66 | HPGD (0.48) | ALDH1A1MAPTCYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |