Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504693 | 0.86 | L3MBTL1 (0.38) | CYP1A2CYP2C19MEN1KMT2AMAPT | |
| SCHEMBL8505812 | 0.86 | ADRB2 (0.42) | HPGDMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8503177 | 0.85 | POLB (0.38) | MEN1KMT2AMAPTALDH1A1THRB | |
| SCHEMBL8504781 | 0.82 | MAPK1 (0.39) | HPGDMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8502094 | 0.81 | MEN1 (0.45) | MEN1KMT2APTGDR2MAPTALDH1A1 | |
| SCHEMBL21352405 | 0.78 | MEN1 (0.39) | HPGDMEN1KMT2AMAPTLMNA | |
| SCHEMBL8526361 | 0.76 | MAPT (0.43) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL8503797 | 0.75 | MAPK1 (0.44) | CYP1A2CYP2C19CYP2D6KMT2AMAPT | |
| SCHEMBL8505614 | 0.74 | NLRP3 (0.41) | MAPTALDH1A1 | |
| SCHEMBL9364036 | 0.73 | CYP1A2 (0.66) | HPGDCYP1A2CYP2C19CYP2D6PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |