Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8503797 | 0.87 | MAPK1 (0.44) | IDO1PTGER1NPC1RAB9AKMT2A | |
| SCHEMBL8505614 | 0.85 | NLRP3 (0.41) | PDE4BIDO1PTGER1KDM4EMAPK1 | |
| SCHEMBL8505812 | 0.85 | ADRB2 (0.42) | GAAIDO1KDM4EMEN1KMT2A | |
| SCHEMBL8504729 | 0.82 | IDO1 (0.41) | GAATSHRIDO1KDM4ERAB9A | |
| SCHEMBL8502514 | 0.80 | IDO1 (0.40) | IDO1KDM4EMEN1KMT2ADOT1L | |
| SCHEMBL8502112 | 0.80 | IDO1 (0.40) | TSHRIDO1KDM4EDOT1LSMN1; SMN2 | |
| SCHEMBL8506457 | 0.79 | IDO1 (0.39) | GAAIDO1KDM4ENPC1RAB9A | |
| SCHEMBL8503177 | 0.78 | POLB (0.38) | GAAIDO1PTGER1MEN1KMT2A | |
| SCHEMBL8504781 | 0.78 | MAPK1 (0.39) | GAAIDO1KDM4ENPC1RAB9A | |
| SCHEMBL8502190 | 0.75 | GAA (0.38) | GAATSHRPDE4BPTGER1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |