Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502112 | 0.91 | IDO1 (0.40) | IDO1DOT1LF2PLAUKLKB1 | |
| SCHEMBL8502514 | 0.91 | IDO1 (0.40) | IDO1DOT1LSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL8506457 | 0.90 | IDO1 (0.39) | IDO1DOT1LSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL8505812 | 0.87 | ADRB2 (0.42) | IDO1HPGDALDH1A1KDM4ENPSR1 | |
| SCHEMBL8503797 | 0.85 | MAPK1 (0.44) | IDO1ELANESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8505614 | 0.83 | NLRP3 (0.41) | IDO1SMN1; SMN2HIF1AALDH1A1KDM4E | |
| SCHEMBL8503700 | 0.83 | POLB (0.43) | IDO1DOT1LSMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL8502188 | 0.82 | GAA (0.38) | IDO1DOT1LSMN1; SMN2KDM4EPTGDR2 | |
| SCHEMBL8503177 | 0.79 | POLB (0.38) | IDO1ALDH1A1NPSR1MEN1POLB | |
| SCHEMBL8501895 | 0.78 | HTT (0.40) | IDO1F2PLAUKLKB1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |