Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504443 | 0.91 | CACNA1B (0.46) | CACNA1BCYP2D6PLA2G4B | |
| SCHEMBL8501935 | 0.88 | EPHX2 (0.39) | CACNA1BCYP2D6SMPD1TSHRMTNR1A | |
| SCHEMBL8506165 | 0.80 | S1PR1 (0.43) | THRATHRB | |
| SCHEMBL8502033 | 0.78 | HSD17B3 (0.45) | THRATHRB | |
| SCHEMBL8504795 | 0.73 | CYSLTR2 (0.53) | CACNA1BCYP2D6SMPD1PLA2G4BTSHR | |
| SCHEMBL20267505 | 0.72 | L3MBTL1 (0.58) | CACNA1BCYP2D6SMPD1PLA2G4BGGPS1 | |
| SCHEMBL4620113 | 0.71 | TSHR (0.54) | CACNA1BCYP2D6SMPD1PLA2G4BGGPS1 | |
| SCHEMBL14544616 | 0.71 | THRB (0.65) | SMPD1THRBNR1H4 | |
| SCHEMBL10778564 | 0.70 | L3MBTL1 (0.62) | CACNA1BCYP2D6SMPD1GGPS1TSHR | |
| SCHEMBL17961074 | 0.69 | SMPD1 (0.68) | SMPD1PLA2G4BTSHRTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948820-A | IMMUNOSUPPRESSANT; PREVENT REJECTION OF ORGAN TRANSPLANT;AUTOIMMUNE DISEASES; MULTIPLE SCLEROSIS; LUPUS; ANTIALLERGENS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-07 | — | — | US | disclosed |