Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.70 |
| ▸ | CA2 | P00918 | 4/20 | 0.70 |
| ▸ | CA1 | P00915 | 3/20 | 0.67 |
| ▸ | ACE | P12821 | 2/20 | 0.63 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PYGL | P06737 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.58 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305154 | 1.00 | PTPN1 (0.70) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL27679107 | 0.94 | CTSL (0.64) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL4359915 | 0.94 | CTSL (0.64) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL4369316 | 0.93 | CTSL (0.63) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL7904964 | 0.93 | CA2 (0.69) | PTPN1CA2CA1ACEITGB1 | |
| SCHEMBL7900484 | 0.93 | CA2 (0.69) | PTPN1CA2CA1ACEITGB1 | |
| SCHEMBL22604693 | 0.90 | CA2 (0.62) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL111236 | 0.89 | ACE (0.76) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL528464 | 0.89 | ACE (0.76) | PTPN1CA2CA1ACECTSL | |
| SCHEMBL111235 | 0.89 | ACE (0.76) | PTPN1CA2CA1ACECTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135810-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS INC (US) | 2019-05-09 | — | — | US | claimed |
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS, INC. | 2012-05-31 | — | — | US | claimed |
| CN-102459263-A | Process for the preparation of substituted tetrahydro beta-carbolines | PTC THERAPEUTICS INC | 2012-05-16 | — | — | CN | claimed |
| US-10947231-B2 | Processes for the preparation of substituted tetrahydro beta-carbolines | PTC THERAPEUTICS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190135810-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS INC (US) | 2019-05-09 | — | — | US | disclosed |
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS, INC. | 2012-05-31 | — | — | US | disclosed |
| CN-102459263-A | Process for the preparation of substituted tetrahydro beta-carbolines | PTC THERAPEUTICS INC | 2012-05-16 | — | — | CN | disclosed |
| US-20070032474-A1 | Use of a compound of formula 1 for making a pharmaceutical composition | BIONDI RICARDO M | 2007-02-08 | — | — | US | disclosed |
| US-20070032474-A1 | Use of a compound of formula 1 for making a pharmaceutical composition | BIONDI RICARDO M | 2007-02-08 | — | — | US | disclosed |
| US-4250183-A | GASTOINTESTINAL DISORDERS; DISEASES OF THE PANCREAS, GALL BLADDER, AND LIVER | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-02-10 | — | — | US | disclosed |
| EP-0003056-A1 | N-substituted omega-aminoalkanoyl-omega-aminoalkanecarboxylic acids, their application and process for their preparation, and medicines containing these compounds | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947231-B2 | Processes for the preparation of substituted tetrahydro beta-carbolines | TPH1, TPH2, HTR1B | PTPN1 4806/4885CA2 2089/4885CA1 1196/4885 |
| US-20070032474-A1 | Use of a compound of formula 1 for making a pharmaceutical composition | CYP7A1, UGT1A1, CYP2F1 | PTPN1 1827/4885CA2 3246/4885CA1 2107/4885 |
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | TPH1, TPH2, HTR1B | PTPN1 4806/4885CA2 2162/4885CA1 1285/4885 |
| US-20190135810-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | TPH1, TPH2, HTR1B | PTPN1 4806/4885CA2 2089/4885CA1 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.