SCHEMBL8512609

SCHEMBL8512609

Cc1cc(C2(c3ccc(O)c(C)c3)CC3CC2CC3c2ccc(C3CC4CC3CC4(c3ccc(O)c(C)c3)c3ccc(O)c(C)c3)cc2)ccc1O

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 7/20 0.42
ESR2 Q92731 6/20 0.42
PDE10A Q9Y233 1/20 0.34
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
POLB P06746 3/20 0.33
GAA P10253 2/20 0.33
GFER P55789 1/20 0.33
TDP1 Q9NUW8 2/20 0.33
TP53 P04637 1/20 0.33
LMNA P02545 2/20 0.32
MAPT P10636 2/20 0.32
XBP1 P17861 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL899859 0.96 ESR2 (0.39) ESR1ESR2PDE10AMEN1KMT2A
SCHEMBL9608266 0.96 ESR1 (0.43) ESR1ESR2PDE10AMEN1KMT2A
SCHEMBL8509615 0.96 ESR1 (0.43) ESR1ESR2PDE10AMEN1KMT2A
SCHEMBL9608272 0.96 ESR1 (0.43) ESR1ESR2PDE10AMEN1KMT2A
SCHEMBL902985 0.92 ESR1 (0.40) ESR1ESR2PDE10AMEN1KMT2A
SCHEMBL899928 0.85 ESR1 (0.38) ESR1ESR2MEN1KMT2APOLB
SCHEMBL899245 0.79 MEN1 (0.33) ESR1ESR2MEN1KMT2APOLB
SCHEMBL899697 0.75 NUDT1 (0.35)
SCHEMBL899767 0.72 ALOX5AP (0.55) ESR1ESR2PDE10AMEN1KMT2A
SCHEMBL9608269 0.71 ESR1 (0.41) ESR1ESR2PDE10AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9261781-B2 Preparation of norbornane-based PAC ballasts SUMITOMO BAKELITE CO., LTD. (JP) 2016-02-16 US disclosed
US-9261781-B2 Preparation of norbornane-based PAC ballasts SUMITOMO BAKELITE CO., LTD. (JP) 2016-02-16 US disclosed
EP-2622410-B1 NORBORNANE-TYPE ARYLOL COMPOUND AND CORRESPONDING PHOTOACTIVE COMPOUND, POSITIVE-TONE PHOTOSENSITIVE RESIN COMPOSITION ENCOMPASSING THE PHOTOACTIVE COMPOUND SUMITOMO BAKELITE CO (JP) 2014-08-20 EP disclosed
EP-2622410-B1 NORBORNANE-TYPE ARYLOL COMPOUND AND CORRESPONDING PHOTOACTIVE COMPOUND, POSITIVE-TONE PHOTOSENSITIVE RESIN COMPOSITION ENCOMPASSING THE PHOTOACTIVE COMPOUND SUMITOMO BAKELITE CO (JP) 2014-08-20 EP disclosed
US-8530133-B2 Preparation of norbornane-based PAC ballasts PROMERUS, LLC (US) 2013-09-10 US disclosed
US-8530133-B2 Preparation of norbornane-based PAC ballasts PROMERUS, LLC (US) 2013-09-10 US disclosed
US-8530133-B2 Preparation of norbornane-based PAC ballasts PROMERUS, LLC (US) 2013-09-10 US disclosed
US-20120135352-A1 Preparation of Norbornane-based PAC Ballasts PROMERUS LLC (US) 2012-05-31 US disclosed
US-20120135352-A1 Preparation of Norbornane-based PAC Ballasts PROMERUS LLC (US) 2012-05-31 US disclosed
US-20120135352-A1 Preparation of Norbornane-based PAC Ballasts PROMERUS LLC (US) 2012-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120135352-A1 Preparation of Norbornane-based PAC Ballasts NBAS, PHB2, BDNF ESR1 2990/4885ESR2 4139/4885PDE10A 780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.