SCHEMBL8514538

SCHEMBL8514538

c1ccc2cc(Sc3c4ccccc4cc4ccccc34)ccc2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP2K2 P36507 2/20 0.43
▸ MAP2K1 Q02750 2/20 0.43
▸ HAO1 Q9UJM8 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ HIF1A Q16665 1/20 0.43
▸ CYP1B1 Q16678 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ LMNA P02545 2/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ CYP1A2 P05177 2/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ KDM1A O60341 1/20 0.42
▸ MAOA P21397 2/20 0.39
▸ USP2 O75604 1/20 0.39
▸ PAK1 Q13153 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3284288 0.83 MEN1 (0.50) ALDH1A1HSD17B10KMT2AHIF1ACYP1B1
SCHEMBL11759729 0.82 MEN1 (0.52) ALDH1A1HSD17B10KMT2AHIF1ACYP1B1
SCHEMBL20591213 0.80 TUBB4A (0.48) ALDH1A1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL14100989 0.80 TUBB4A (0.42) MAP2K2MAP2K1HAO1ALDH1A1LMNA
SCHEMBL761802 0.79 LMNA (0.57) MAP2K2MAP2K1HAO1ALDH1A1HSD17B10
SCHEMBL30832956 0.79 LMNA (0.57) MAP2K2MAP2K1HAO1ALDH1A1HSD17B10
SCHEMBL11300299 0.77 ALDH1A1 (0.50) MAP2K2MAP2K1HAO1ALDH1A1HSD17B10
SCHEMBL18162299 0.75 HPRT1 (0.50) HAO1ALDH1A1KMT2AMEN1NPC1
SCHEMBL30548745 0.73 MAP2K2 (0.48) MAP2K2MAP2K1HAO1ALDH1A1HSD17B10
SCHEMBL3281214 0.73 LMNA (0.52) MAP2K2MAP2K1HAO1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8932797-B2 Photoacid generators DOW GLOBAL TECHNOLOGIES LLC (US) 2015-01-13 — — US disclosed
US-20120141939-A1 PHOTOACID GENERATORS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2012-06-07 — — US disclosed
EP-2458440-A1 Photoacid generators Rohm and Haas Electronic Materials LLC (US) 2012-05-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120141939-A1 PHOTOACID GENERATORS F10, GNG2, H1-0 MAP2K2 3802/4885MAP2K1 3937/4885HAO1 1978/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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