Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | HAT1 | O14929 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613034 | 0.92 | KIF11 (0.47) | KIF11SERPINE1TDP1KDM4ESTING1 | |
| SCHEMBL8512623 | 0.87 | NPC1 (0.47) | KDM4EMAPTKMT2AMAPK10 | |
| SCHEMBL8514278 | 0.84 | KIF11 (0.42) | ESR1KIF11FFAR1FFAR4HAT1 | |
| SCHEMBL8532964 | 0.84 | MAT2A (0.52) | ESR1KIF11CDK8NTRK3TDP1 | |
| SCHEMBL8537609 | 0.84 | KIF11 (0.44) | ESR1KIF11CDK8NTRK3TDP1 | |
| SCHEMBL8512448 | 0.80 | KMT2A (0.50) | TDP1KDM4EMAPTKMT2AMAPK10 | |
| SCHEMBL7455829 | 0.77 | TUBB4A (0.57) | TDP1KDM4EMAPTKMT2A | |
| SCHEMBL8537300 | 0.77 | KIF11 (0.46) | KIF11SERPINE1TDP1STING1MAPT | |
| SCHEMBL6280799 | 0.76 | KDM4E (0.59) | ESR1TDP1KDM4EKMT2A | |
| SCHEMBL8538008 | 0.76 | CTSV (0.63) | KIF11KDM4EKMT2ACTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108697705-A | combination product | 利物浦热带医学院 | 2018-10-23 | — | — | CN | claimed |
| CN-108697705-A | combination product | 利物浦热带医学院 | 2018-10-23 | — | — | CN | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |