Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 7/20 | 0.53 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551665 | 0.89 | CACNA1B (0.47) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 | |
| SCHEMBL8357917 | 0.88 | HTT (0.48) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 | |
| SCHEMBL8550957 | 0.87 | CACNA1B (0.44) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 | |
| SCHEMBL8551381 | 0.87 | CACNA1B (0.45) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 | |
| SCHEMBL8516569 | 0.86 | MAPT (0.44) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 | |
| SCHEMBL8358041 | 0.85 | KMT2A (0.52) | LMNACYP1A2CYP2D6MAPTPPARA | |
| SCHEMBL8355838 | 0.85 | LTA4H (0.56) | LMNACYP1A2CYP2D6MAPTAURKB | |
| SCHEMBL8551252 | 0.85 | LMNA (0.50) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 | |
| SCHEMBL8359679 | 0.83 | MAPT (0.61) | CYP1A2MAPTCSNK1D | |
| SCHEMBL8554328 | 0.81 | LMNA (0.48) | CACNA1BCACNA1HLMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919807-A | ANTICHOLESTEROL AGENTS | DR. KARL THOMAE GMBH (DE) | 1999-07-06 | — | — | US | disclosed |
| EP-0824529-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035681-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-11-14 | — | — | WO | disclosed |