SCHEMBL8516977

SCHEMBL8516977

CC(=O)On1c(=O)c(-c2cn(CCCCN)c3ccccc23)nc2c(-c3ccccc3)cccc21

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CAMK2D Q13557 12/20 0.46
CNR2 P34972 4/20 0.41
CNR1 P21554 1/20 0.41
PIM1 P11309 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8516793 0.97 CAMK2D (0.48) CAMK2DCNR2CNR1PIM1
SCHEMBL8515897 0.89 CAMK2D (0.44) CAMK2DPIM1
SCHEMBL8516344 0.89 CAMK2D (0.40) CAMK2DCNR2
SCHEMBL8516339 0.86 F2RL3 (0.44) CNR2
SCHEMBL8516735 0.86 IGF1R (0.40) CAMK2D
SCHEMBL8516619 0.86 ASH1L (0.43) CAMK2D
SCHEMBL8516993 0.86 CAMK2D (0.37) CAMK2DCNR2
SCHEMBL8515918 0.85 IGF1R (0.39) CAMK2DCNR2CNR1
SCHEMBL8516327 0.85 CAMK2D (0.46) CAMK2DCNR2CNR1PIM1
SCHEMBL8365275 0.85 CAMK2D (0.37) CAMK2DCNR2CNR1PIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO claimed
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO disclosed