Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.46 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519617 | 0.86 | ALDH1A1 (0.57) | ALDH1A1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL10974445 | 0.84 | ALDH1A1 (0.50) | ALDH1A1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8519769 | 0.81 | ALDH1A1 (0.54) | ALDH1A1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL11226270 | 0.80 | ALDH1A1 (0.43) | ALDH1A1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL11224840 | 0.80 | ALDH1A1 (0.43) | ALDH1A1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL14087515 | 0.78 | ALDH1A1 (0.55) | ALDH1A1AR | |
| SCHEMBL8351343 | 0.77 | ALDH1A1 (0.79) | ALDH1A1CYP2C19 | |
| SCHEMBL7515733 | 0.76 | ABCC9 (0.68) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL10984365 | 0.75 | AR (0.54) | ARCYP2C19 | |
| SCHEMBL5199230 | 0.74 | L3MBTL1 (0.46) | ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0002309-B1 | ACYLANILIDES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL AND VETERINARY COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-01 | — | — | EP | disclosed |
| US-4282218-A | ANTIANDROGENS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4239776-A | Anti-androgenic amides | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-16 | — | — | US | disclosed |
| EP-0002309-A2 | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-06-13 | — | — | EP | disclosed |