Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9466376 | 0.77 | HTR1A (0.56) | HTR1ADRD2 | |
| SCHEMBL9175441 | 0.72 | HTR1A (0.57) | HTR1ADRD2 | |
| SCHEMBL7812155 | 0.68 | DRD2 (0.49) | HTR1ADRD2 | |
| SCHEMBL8303446 | 0.66 | HTR1A (0.93) | HTR1ADRD2 | |
| SCHEMBL9176466 | 0.65 | SLC6A2 (0.37) | HTR1AHTR7 | |
| SCHEMBL7534943 | 0.63 | ADRB1 (0.62) | HTR1ADRD2HTR7 | |
| SCHEMBL9181453 | 0.62 | KMT2A (0.41) | — | |
| SCHEMBL9722314 | 0.62 | MAOA (0.40) | — | |
| SCHEMBL156160 | 0.61 | MAOA (0.54) | — | |
| SCHEMBL7134969 | 0.61 | TSHR (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990114-A | ADMINISTERING 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES OF GIVEN FORMULA TO TREAT NEUROMUSCULAR DYSFUNCTION OF THE LOWER URINARY TRACT; BOTH PRE- AND POST-SYNAPTIC ANTAGONISM; SUCH AS 1-(2-((2-PYRIDYLAMINO)ETHYL)-4-(4-INDOLYL)PIPERAZINE | RECORDATI, S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-11-23 | — | — | US | disclosed |