Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520906 | 1.00 | JAK2 (0.35) | JAK2NTRK1MAPK14PDGFRBPDGFRA | |
| SCHEMBL8444635 | 0.84 | EPHA2 (0.36) | PDGFRBPDGFRAEPHA2KDM4EALDH1A1 | |
| SCHEMBL8436900 | 0.77 | EPHA2 (0.42) | PDGFRBPDGFRAEPHA2KDM4EALDH1A1 | |
| SCHEMBL8438071 | 0.76 | KDR (0.38) | PDGFRBPDGFRAEPHA2KDM4EALDH1A1 | |
| SCHEMBL8444662 | 0.76 | EPHA2 (0.44) | PDGFRBPDGFRAEPHA2KDM4EALDH1A1 | |
| SCHEMBL6269488 | 0.75 | EGFR (0.42) | PDGFRBPDGFRAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5618725 | 0.74 | EHMT2 (0.51) | EPHA2KDR | |
| SCHEMBL6266570 | 0.74 | EGFR (0.46) | EPHA2KDR | |
| SCHEMBL6266311 | 0.73 | EGFR (0.44) | PDGFRBPDGFRAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28962458 | 0.73 | EPHA2 (0.45) | EPHA2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892799-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1999-01-27 | — | — | EP | claimed |
| WO-1997038994-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-10-23 | — | — | WO | claimed |