SCHEMBL852468

SCHEMBL852468

CC(C)(C)[Si](C)(C)OCCCC=O

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DUT P33316 2/20 0.40
HIF1A Q16665 1/20 0.36
TSHR P16473 2/20 0.36
MAPT P10636 1/20 0.32
FAAH O00519 2/20 0.30
TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL201004 0.94 DUT (0.39) DUTHIF1ATSHRFAAHTRPV1
SCHEMBL1008596 0.92 TSHR (0.40) DUTHIF1ATSHRFAAHTRPV1
SCHEMBL31240526 0.92 TSHR (0.40) DUTHIF1ATSHRFAAHTRPV1
SCHEMBL2917304 0.92 TSHR (0.40) DUTHIF1ATSHRFAAHTRPV1
SCHEMBL27241090 0.92 TSHR (0.40) DUTHIF1ATSHRFAAHTRPV1
SCHEMBL573170 0.87 DUT (0.35) DUT
SCHEMBL20573300 0.81 DUT (0.36) DUTTSHR
SCHEMBL27040101 0.81 DUT (0.37) DUT
SCHEMBL4455945 0.81 DUT (0.37) DUTTSHR
SCHEMBL29102792 0.80 DUT (0.41) DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119707725-A Preparation method of 4-amino-5-hexenoate hydrochloride 新乡学院 2025-03-28 CN claimed
CN-119463663-A Corrosion-resistant stainless steel seamless steel pipe and manufacturing method thereof 浙江邦诺钢管有限公司 2025-02-18 CN claimed
EP-0360246-A1 3-Oxiranyl benzoic acids and derivatives thereof G.D. Searle & Co. (US) 1990-03-28 EP claimed
EP-4104902-B1 COMPOUNDS AND MEDICAMENTS USING SAME IRIMAJIRI THERAPEUTICS INC (JP) 2026-05-27 EP disclosed
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECH LIMITED (GB) 2026-05-21 US disclosed
US-12623988-B2 Scaleable preparation of polyketides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-05-12 US disclosed
EP-4658636-A1 LIPID COMPOUNDS AND USES THEREOF Pfizer Inc. (US) 2025-12-10 EP disclosed
US-12473295-B2 Substituted straight chain spiro derivatives JANSSEN PHARMACEUTICA NV (BE) 2025-11-18 US disclosed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
EP-4577526-A1 VHH ANTIBODY CONJUGATES Abdera Therapeutics Inc. (US) 2025-07-02 EP disclosed
WO-2025134066-A1 IONIZABLE LIPIDS BIONTECH DELIVERY TECHNOLOGIES GMBH (DE) 2025-06-26 WO disclosed
US-20020007060-A1 Reverse hydroxamate inhibitors of matrix metalloproteinases DAVIDSEN STEVEN K (US) 2002-01-17 US disclosed
EP-1159263-A1 NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF Merck & Co., Inc. (US) 2001-12-05 EP disclosed
US-6294573-B1 FOR THERAPY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPENIAS SUCH AS OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL, EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR GROWTH AND METASTASIS OR INVASION ABBOTT LABORATORIES 2001-09-25 US disclosed
WO-2000050391-A1 NOVEL SULFONAMIDE COMPOUNDS AND USES THEREOF MERCK & CO., INC. (US) 2000-08-31 WO disclosed
US-5990326-A AN ANTIINFLAMMATORY AGENT AS INHIBITORS OF LEUKOTRIENE HYDROLASE G.D. SEARLE & CO. (US) 1999-11-23 US disclosed
US-5411969-A Antihyperlipidemic/antioxidant dihydroquinolines BRISTOL-MYERS SQUIBB COMPANY (US) 1995-05-02 US disclosed
US-5336771-A Certain 3,4-dihydro-2H-pyrano[2,3-b]pyridines PFIZER INC. (US) 1994-08-09 US disclosed
EP-0360246-B1 3-Oxiranyl benzoic acids and derivatives thereof SEARLE & CO (US) 1994-03-30 EP disclosed
EP-0360246-A1 3-Oxiranyl benzoic acids and derivatives thereof G.D. Searle & Co. (US) 1990-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137703-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER EGFR, KRAS, O60361 DUT 1465/4885HIF1A 3360/4885TSHR 590/4885
US-12623988-B2 Scaleable preparation of polyketides SF3B5, RPS5, RPS25 DUT 519/4885HIF1A 1199/4885TSHR 3595/4885
US-12473295-B2 Substituted straight chain spiro derivatives MLLT1, MEN1, MLLT3 DUT 4220/4885HIF1A 3180/4885TSHR 3952/4885
US-20020007060-A1 Reverse hydroxamate inhibitors of matrix metalloproteinases MMP1, MMP9, MMP3 DUT 536/4885HIF1A 608/4885TSHR 3628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.