Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105268 | 0.80 | PTGS2 (0.40) | HTTPTGS2PTGS1MAPTPKM | |
| SCHEMBL21786210 | 0.72 | PTGS1 (0.68) | POLBPTGS2PTGS1MAPTKEAP1 | |
| SCHEMBL8524053 | 0.71 | GUSB (0.41) | HTTPTGS2PTGS1MAPTKEAP1 | |
| SCHEMBL8101641 | 0.71 | PKM (0.47) | POLBHTTMAPTPKMALDH1A1 | |
| SCHEMBL8525054 | 0.70 | ALDH1A1 (0.41) | HTTPTGS2PTGS1MAPTKEAP1 | |
| SCHEMBL8101780 | 0.69 | LMNA (0.53) | POLBHTTMAPTPKMTP53 | |
| SCHEMBL2068498 | 0.67 | KEAP1 (0.65) | HTTPTGS2PTGS1KEAP1NFE2L2 | |
| SCHEMBL29904739 | 0.67 | KEAP1 (0.65) | HTTPTGS2PTGS1KEAP1NFE2L2 | |
| SCHEMBL10622738 | 0.67 | PTGS2 (0.41) | PTGS2PTGS1MAPTKEAP1NFE2L2 | |
| SCHEMBL28353371 | 0.67 | MAPT (0.53) | POLBHTTMAPTPKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |