Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 17/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 10/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527038 | 0.90 | DRD3 (0.55) | DRD3DRD2SIGMAR1DRD4 | |
| Hydrochloric Acid SCHEMBL8528848 | 0.89 | DRD3 (0.54) | DRD3DRD2SIGMAR1DRD4 | |
| SCHEMBL8525974 | 0.82 | PRMT5 (0.51) | DRD3CYP1A2HTR1AADRA2ACYP2D6 | |
| SCHEMBL8528789 | 0.77 | DRD3 (0.79) | DRD3DRD2SIGMAR1DRD4 | |
| SCHEMBL8529262 | 0.77 | SIGMAR1 (0.48) | DRD3DRD2SIGMAR1DRD4 | |
| SCHEMBL14052308 | 0.76 | LMNA (0.47) | DRD3DRD2SIGMAR1DRD4 | |
| SCHEMBL8967226 | 0.76 | SIGMAR1 (0.66) | DRD3SIGMAR1 | |
| SCHEMBL8525948 | 0.75 | DRD3 (0.78) | DRD3DRD2SIGMAR1 | |
| SCHEMBL11946667 | 0.75 | ADRA2A (0.76) | DRD3CYP1A2HTR1AADRA2ACYP2D6 | |
| SCHEMBL8526356 | 0.75 | RAD52 (0.55) | DRD3CYP1A2DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | claimed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | claimed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| US-5498628-A | ANTIPSYCHOTIC, PSYCHOSTIMULATORY, ANTIAUTISTIC, ANTIDEPRESSANT AND HYPOTENSIVE AGENTS, PARKINSON'S DISEASE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-03-12 | — | — | US | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |