Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | CCKAR | P32238 | 1/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8531003 | 0.94 | REN (0.49) | RENMAPK1PSMB5 | |
| SCHEMBL8527595 | 0.92 | CTSS (0.51) | RENMAPK1SCN9ACTSSCTSL | |
| SCHEMBL8527394 | 0.87 | ALDH1A1 (0.47) | RENPSMB5CAPN1 | |
| SCHEMBL8529149 | 0.83 | BACE1 (0.44) | CAPN1 | |
| SCHEMBL31628521 | 0.79 | SCN9A (0.65) | RENSCN9ACTSSCTSLCTSB | |
| SCHEMBL19341935 | 0.79 | REN (0.71) | RENMAPK1CTSSCTSLCTSB | |
| SCHEMBL3499528 | 0.79 | REN (0.71) | RENMAPK1CTSSCTSLCTSB | |
| SCHEMBL17629479 | 0.79 | REN (0.71) | RENMAPK1CTSSCTSLCTSB | |
| SCHEMBL21244275 | 0.79 | REN (0.71) | RENMAPK1CTSSCTSLCTSB | |
| SCHEMBL3824374 | 0.79 | REN (0.71) | RENMAPK1CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |