Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527225 | 0.94 | REN (0.55) | RENMAPK1PSMB5 | |
| SCHEMBL8529149 | 0.88 | BACE1 (0.44) | CTSDBACE1 | |
| SCHEMBL8527595 | 0.86 | CTSS (0.51) | RENKMT2AMAPK1 | |
| SCHEMBL8527394 | 0.84 | ALDH1A1 (0.47) | RENPSMB5 | |
| SCHEMBL8530799 | 0.81 | REN (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8530164 | 0.78 | PSEN1 (0.59) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8530092 | 0.76 | CTSS (0.72) | REN | |
| SCHEMBL8528279 | 0.76 | PSEN1 (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13388507 | 0.76 | REN (0.64) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8132515 | 0.76 | PSMB5 (0.60) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |