Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.50 |
| ▸ | CCKAR | P32238 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 4/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527225 | 0.92 | REN (0.55) | CTSSCTSLCTSBCTSKSCN9A | |
| SCHEMBL8531003 | 0.86 | REN (0.49) | KMT2ARENMAPK1 | |
| SCHEMBL31628521 | 0.84 | SCN9A (0.65) | CTSSCTSLCTSBCTSKSCN9A | |
| SCHEMBL27616185 | 0.79 | ACE (0.59) | CTSSCTSLCTSBCTSKCCKAR | |
| SCHEMBL11030896 | 0.79 | ACE (0.59) | CTSSCTSLCTSBCTSKCCKAR | |
| SCHEMBL7705336 | 0.78 | EPHX2 (0.53) | CTSSCTSLCTSBCTSKSCN9A | |
| SCHEMBL3870531 | 0.78 | EPHX2 (0.53) | CTSSCTSLCTSBCTSKSCN9A | |
| SCHEMBL8527394 | 0.77 | ALDH1A1 (0.47) | REN | |
| SCHEMBL26508667 | 0.77 | CTSS (0.53) | CTSSCTSLCTSBCTSKSCN9A | |
| SCHEMBL7321427 | 0.75 | ACE (0.56) | CTSSCTSLCTSBCTSKSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |