Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | CPA2 | P48052 | 1/20 | 0.42 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CTSE | P14091 | 1/20 | 0.42 |
| ▸ | PGC | P20142 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527394 | 0.94 | ALDH1A1 (0.47) | CPA1CPB1CPA2CPA4ACE2 | |
| SCHEMBL8531003 | 0.88 | REN (0.49) | BACE1CTSD | |
| SCHEMBL8527225 | 0.83 | REN (0.55) | CAPN1 | |
| SCHEMBL7421185 | 0.76 | CPA1 (0.59) | BACE1CPA1CPB1CPA2CPA4 | |
| SCHEMBL8527595 | 0.74 | CTSS (0.51) | — | |
| SCHEMBL8529162 | 0.73 | CTSL (0.55) | CPA1CPB1CPA2CPA4ACE2 | |
| SCHEMBL7419119 | 0.72 | CPA1 (0.53) | BACE1CPA1CPB1CPA2CPA4 | |
| SCHEMBL29112224 | 0.72 | MME (0.58) | BACE1CPA1ACE2 | |
| SCHEMBL6248305 | 0.71 | CTSB (0.55) | CPA1CPB1CPA2CPA4ACE2 | |
| SCHEMBL7270319 | 0.71 | CTSS (0.52) | CPA1ACE2CTSDALDH1A1CTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |