SCHEMBL8530661

SCHEMBL8530661

COc1ccc(-c2[c]ccc(C#N)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.41
KDM4E B2RXH2 2/20 0.40
AR P10275 2/20 0.40
PGR P06401 1/20 0.40
SNCA P37840 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
ADORA1 P30542 1/20 0.39
MEN1 O00255 2/20 0.38
ALDH1A1 P00352 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 2/20 0.38
TSHR P16473 1/20 0.38
HTT P42858 1/20 0.38
GSK3B P49841 1/20 0.38
HPGDS O60760 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
GAA P10253 1/20 0.38
MAPKAPK2 P49137 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15821233 0.84 THRB (0.41) THRBSNCARXFP1MEN1KMT2A
SCHEMBL9739115 0.83 MMP3 (0.42) PGRALDH1A1TSHRGSK3BMAOA
SCHEMBL7194431 0.81 ALDH1A1 (0.47) ARALDH1A1GSK3BMAOAMAOB
SCHEMBL8527203 0.81 CHEK2 (0.47) KDM4EPGRMEN1ALDH1A1KMT2A
SCHEMBL459934 0.79 CA12 (0.44) THRBKDM4ERXFP1ALDH1A1MAPT
SCHEMBL8528175 0.79 CYP1A1 (0.46) ARSNCAADORA1ALDH1A1TSHR
SCHEMBL1978737 0.78 APP (0.41) PGRALDH1A1
SCHEMBL15818998 0.78 MAOA (0.39) KDM4ERXFP1ALDH1A1MAPTTSHR
SCHEMBL9634014 0.78 MMP3 (0.52) AR
SCHEMBL1819607 0.78 MEN1 (0.41) ARMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5749925-A Dyeing or printing process with new and known cationic 4,5-dihydro-iH-1,2,3-triazolium compounds as dyestuffs and new cationic 4,5-dihydro-1H-1,2,3-triazolium compounds BAYER AKTIENGESELLSCHAFT (DE) 1998-05-12 US disclosed