Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9067917 | 0.81 | ALDH1A1 (0.41) | KMT2AGAALMNATSHRALDH1A1 | |
| SCHEMBL8530333 | 0.80 | HSD17B10 (0.32) | HSD17B10 | |
| SCHEMBL7238348 | 0.76 | KMT2A (0.37) | KMT2AGAALMNAKDM4ETSHR | |
| SCHEMBL7052659 | 0.74 | HSD17B10 (0.41) | KMT2AGAAMMELMNAKDM4E | |
| SCHEMBL8530708 | 0.73 | ALDH1A1 (0.37) | KMT2AGAALMNAALDH1A1STAT3 | |
| SCHEMBL7238354 | 0.73 | ALDH1A1 (0.37) | KMT2AGAALMNAKDM4ETSHR | |
| SCHEMBL9067915 | 0.72 | LMNA (0.39) | KMT2AGAALMNATSHRALDH1A1 | |
| SCHEMBL8528855 | 0.71 | HSD17B10 (0.35) | KMT2AMMELMNAALDH1A1HSD17B10 | |
| SCHEMBL3483299 | 0.70 | STAT3 (0.42) | KMT2AALDH1A1STAT3CA2CA9 | |
| SCHEMBL8530445 | 0.70 | KMT2A (0.39) | KMT2AGAAMMELMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773428-A | BONE DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0807114-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1997-11-19 | — | — | EP | disclosed |