Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534081 | 0.82 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3DRD2DRD3 | |
| SCHEMBL8473063 | 0.82 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3DRD2DRD3 | |
| SCHEMBL13664778 | 0.76 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL13664680 | 0.76 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3HTR1A | |
| SCHEMBL28472285 | 0.74 | SLC6A2 (0.55) | SLC6A4SLC6A2SLC6A3DRD2HTR3E | |
| SCHEMBL28470764 | 0.74 | SLC6A2 (0.55) | SLC6A4SLC6A2SLC6A3DRD2HTR3E | |
| Hydrochloric Acid SCHEMBL7258862 | 0.73 | DHFR (0.40) | SLC6A4SLC6A2SLC6A3DRD2DRD3 | |
| SCHEMBL13664679 | 0.73 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3HTR3EHTR3B | |
| SCHEMBL7344849 | 0.71 | ALOX5 (0.59) | SLC6A4DRD2DRD3KCNH2HTR1A | |
| SCHEMBL8534451 | 0.71 | ADRB1 (0.55) | SLC6A4HTR1ACYP2D6HTR2AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739334-A | CHEMICAL INTERMEDIATES FOR NEW ANTIDEPRESSANT WITH SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |
| US-5726178-A | Alkyl derivatives of trazodone with CNS activity | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-03-10 | — | — | US | disclosed |
| US-5543563-A | ANTIDEPRESSANTS; SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1996-08-06 | — | — | US | disclosed |
| EP-0623131-B1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ANGELINI RICERCHE SPA (IT) | 1996-04-03 | — | — | EP | disclosed |
| EP-0623131-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY. | ANGELINI FRANCESCO IST RICERCA (IT) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014091-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1993-07-22 | — | — | WO | disclosed |