Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.33 |
| ▸ | CA2 | P00918 | 8/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.32 |
| ▸ | CA12 | O43570 | 4/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.31 |
| ▸ | CASR | P41180 | 2/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533935 | 0.74 | F10 (0.33) | — | |
| SCHEMBL8531518 | 0.73 | CA1 (0.34) | CA1CA2CA4CA9CA12 | |
| SCHEMBL8536130 | 0.72 | CA1 (0.35) | CA1CA2CA4CA9CA12 | |
| SCHEMBL8536127 | 0.71 | CA1 (0.35) | CA1CA2CA9CA12MAPT | |
| SCHEMBL8536202 | 0.70 | FFAR1 (0.35) | CA1CA2CA4CA9CA12 | |
| SCHEMBL8499997 | 0.68 | PFKFB3 (0.41) | CA1CA2MAPTPFKFB3MEN1 | |
| SCHEMBL8501213 | 0.66 | CA12 (0.40) | CA1CA2CA9CA12ITGB3 | |
| SCHEMBL8531726 | 0.65 | WDR5 (0.32) | ITGB1MAPT | |
| SCHEMBL7372870 | 0.65 | KMT2A (0.53) | CA1CA2CA9CA12ITGB1 | |
| SCHEMBL8369244 | 0.63 | ITGB3 (0.61) | ITGB1ITGB3ITGAVITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773646-A | INTEGRIN INHIBITORS | G. D. SEARLE & CO. (US) | 1998-06-30 | — | — | US | disclosed |