Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.44 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8535164 | 1.00 | AGBL2 (0.57) | AGBL2ATMKDM4EL3MBTL1PLA2G1B | |
| SCHEMBL8533439 | 0.89 | ATM (0.55) | AGBL2ATMKDM4EL3MBTL1PLA2G1B | |
| Maleic Acid SCHEMBL8530058 | 0.83 | GAA (0.47) | ATMKDM4EL3MBTL1PLA2G1BNPSR1 | |
| Fumaric Acid SCHEMBL8530062 | 0.83 | GAA (0.47) | ATMKDM4EL3MBTL1PLA2G1BNPSR1 | |
| Fumaric Acid SCHEMBL8529731 | 0.82 | AGBL2 (0.52) | AGBL2SLC6A4SLC6A2SLC6A3GAA | |
| Maleic Acid SCHEMBL8529729 | 0.82 | AGBL2 (0.52) | AGBL2SLC6A4SLC6A2SLC6A3GAA | |
| SCHEMBL4731272 | 0.80 | AGBL2 (0.81) | AGBL2KDM4ERXRA | |
| SCHEMBL8531089 | 0.79 | SLC6A4 (0.59) | ATMKDM4EL3MBTL1PLA2G1BNPSR1 | |
| Maleic Acid SCHEMBL8587758 | 0.74 | GAA (0.51) | AGBL2SLC6A4SLC6A2SLC6A3GAA | |
| Fumaric Acid SCHEMBL8587760 | 0.74 | GAA (0.51) | AGBL2SLC6A4SLC6A2SLC6A3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859757-A1 | DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS | Farmak A.S. (CZ) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997017325-A1 | DERIVATES OF N,N-DIMETHYL-2-(ARYLTHIO)BENZYLAMINE, THEIR SALTS, METHODS OF PREPARATION AND THEIR USE IN PHARMACEUTICAL MEDICAMENTS | FARMAK A.S. (CZ) | 1997-05-15 | — | — | WO | disclosed |