Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542321 | 0.89 | PTGDR2 (0.56) | TBXAS1PTGDR2HTR6RORCTP53 | |
| SCHEMBL8539183 | 0.88 | HTR6 (0.52) | TBXAS1PTGDR2TBXA2RHTR6RORC | |
| SCHEMBL3154394 | 0.82 | HTR6 (0.75) | HTR6RORCTP53PKMSMN1; SMN2 | |
| SCHEMBL27650861 | 0.78 | PKM (0.50) | HTR6RORCTP53PKMSMN1; SMN2 | |
| SCHEMBL8539417 | 0.78 | HTR6 (0.52) | PTGDR2HTR6RORCTP53PKM | |
| SCHEMBL8539271 | 0.77 | TBXAS1 (0.79) | TBXAS1PTGDR2TBXA2R | |
| SCHEMBL3194262 | 0.76 | SERPINE1 (0.57) | PTGDR2HTR6 | |
| SCHEMBL8537438 | 0.75 | TBXAS1 (0.70) | TBXAS1PTGDR2TBXA2R | |
| SCHEMBL8539522 | 0.74 | TBXAS1 (1.00) | TBXAS1PTGDR2TBXA2R | |
| SCHEMBL3153464 | 0.74 | HTR6 (0.72) | HTR6TP53PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | claimed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | claimed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | claimed |