Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539417 | 0.90 | HTR6 (0.52) | HTR6RORCPKMTP53ATM | |
| SCHEMBL8537431 | 0.88 | TBXAS1 (0.58) | HTR6RORCPKMTP53SMN1; SMN2 | |
| SCHEMBL3154394 | 0.82 | HTR6 (0.75) | HTR6RORCPKMTP53SMN1; SMN2 | |
| SCHEMBL8539906 | 0.79 | TBXAS1 (0.65) | RORCPKMTP53SMN1; SMN2TBXAS1 | |
| SCHEMBL27650861 | 0.78 | PKM (0.50) | HTR6RORCPKMTP53SMN1; SMN2 | |
| SCHEMBL8542321 | 0.78 | PTGDR2 (0.56) | HTR6RORCTP53TBXAS1PTGDR2 | |
| SCHEMBL8581509 | 0.77 | TBXAS1 (0.61) | PKMTP53SMN1; SMN2TBXAS1EGFR | |
| SCHEMBL8539463 | 0.76 | TBXAS1 (0.83) | TBXAS1 | |
| SCHEMBL8539323 | 0.75 | TBXAS1 (0.61) | RORCPKMTP53SMN1; SMN2TBXAS1 | |
| SCHEMBL19150402 | 0.75 | KMO (0.55) | SMN1; SMN2ATMALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |