Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686254 | 0.97 | TSHR (0.47) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| Hydrochloric Acid SCHEMBL715477 | 0.93 | KDM4E (0.50) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| Water SCHEMBL2032857 | 0.93 | TSHR (0.44) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| Bromide SCHEMBL14890342 | 0.93 | MEN1 (0.47) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| Hydrochloric Acid SCHEMBL2581079 | 0.93 | KDM4E (0.50) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| SCHEMBL1686196 | 0.90 | TSHR (0.47) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| SCHEMBL476985 | 0.90 | TSHR (0.47) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| SCHEMBL20175892 | 0.88 | SLC22A1 (0.50) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| SCHEMBL28465660 | 0.88 | SLC22A1 (0.50) | KDM4EPMP22ATMCYP3A4SLC5A7 | |
| Fluoride Ion SCHEMBL17870608 | 0.87 | TSHR (0.44) | KDM4EPMP22ATMCYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344303-B1 | MENISCAL REPAIR ADHESIVE | ARTHREX INC (US) | 2021-08-04 | — | — | EP | disclosed |
| US-20210038761-A1 | MENISCAL REPAIR ADHESIVE | ARTHTEX, INC. (US) | 2021-02-11 | — | — | US | disclosed |
| US-10850005-B2 | Meniscal repair adhesive | ARTHREX, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20200085998-A1 | Meniscal Repair Adhesive | COHERA MEDICAL, INC. | 2020-03-19 | — | — | US | disclosed |
| EP-2432399-B1 | DEVICE FOR DELIVERING ADHESIVE | COHERA MEDICAL INC (US) | 2018-09-05 | — | — | EP | disclosed |
| US-20180217551-A1 | ELECTROPHOTOGRAPHIC MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | CANON KK (JP) | 2018-08-02 | — | — | US | disclosed |
| EP-3344303-A1 | MENISCAL REPAIR ADHESIVE | Cohera Medical, Inc. (US) | 2018-07-11 | — | — | EP | disclosed |
| US-9964914-B2 | Electrophotographic member, process cartridge, and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2018-05-08 | — | — | US | disclosed |
| WO-2017040569-A1 | MENISCAL REPAIR ADHESIVE | COHERA MEDICAL, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20170056549-A1 | Meniscal Repair Adhesive | DSI ASSIGNMENTS, LLC | 2017-03-02 | — | — | US | disclosed |
| US-20090112255-A1 | SPRAY DEVICES AND METHODS | COHERA MEDICAL, INC. (US) | 2009-04-30 | — | — | US | disclosed |
| US-20090028812-A1 | HYDROPHILIC BIODEGRADABLE ADHESIVES | COHERA MEDICAL, INC. | 2009-01-29 | — | — | US | disclosed |
| WO-2009014886-A2 | HYDROPHILIC BIODEGRADABLE ADHESIVES | COHERA MEDICAL, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| EP-0328020-B1 | Use of a catalyst in epoxy compositions | DOW CHEMICAL CO (US) | 1996-10-09 | — | — | EP | disclosed |
| EP-0553887-A2 | Catalysts and epoxy resin composition containing the same | THE DOW CHEMICAL COMPANY (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1991011986-A1 | MOUTH WASHES AND DENTIFRICES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1991-08-22 | — | — | WO | disclosed |
| US-4946817-A | REACTION PRODUCT OF TETRASUBSTITUTED ONIUM COMPOUND WITH ACID OR METAL SALT OF WEAK NUCLEOPHILIC ANION | THE DOW CHEMICAL COMPANY (US) | 1990-08-07 | — | — | US | disclosed |
| US-4925901-A | STORAGE STAABILITY, ONIUM ION CATALYST | THE DOW CHEMICAL COMPANY (US) | 1990-05-15 | — | — | US | disclosed |
| EP-0328020-A2 | Use of a catalyst in epoxy compositions | THE DOW CHEMICAL COMPANY (US) | 1989-08-16 | — | — | EP | disclosed |
| EP-0025926-B1 | PROCESS FOR THE PREPARATION OF MONOAROYLATED 1,4-DIAMINO ANTHRAQUINONES | BAYER AG (DE) | 1982-11-24 | — | — | EP | disclosed |