Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAP2 | P11137 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057850 | 0.95 | MYC (0.36) | MYCIKBKB | |
| SCHEMBL8910392 | 0.88 | CCNB2 (0.32) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL8142537 | 0.88 | MYC (0.34) | MYCKMT2ACCNB2CDK1CCNB1 | |
| SCHEMBL8536552 | 0.86 | GAA (0.32) | ALDH1A1 | |
| SCHEMBL8149445 | 0.83 | TERT (0.36) | MEN1KMT2A | |
| SCHEMBL8910714 | 0.82 | ALDH1A1 (0.34) | MEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL8909578 | 0.82 | HPGD (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL8796475 | 0.82 | MYC (0.35) | MYCIKBKBMEN1KMT2ACCNB2 | |
| SCHEMBL8154324 | 0.80 | LMNA (0.35) | — | |
| SCHEMBL8146941 | 0.80 | GRIN1 (0.39) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770598-A | ANTITUMOR AGENTS; REACTING WITH CARBONYL DIIMIDAZOLE AND AMIDOXIMES | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |