SCHEMBL8540309

SCHEMBL8540309

CCO/N=C(\C(=O)NC)c1ccccc1/C(ON)=C(C)/C(=N\OC)c1ccc(OC2CCCC2)cc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
HTT P42858 3/20 0.36
MAPT P10636 2/20 0.36
LMNA P02545 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
PARP10 Q53GL7 1/20 0.33
ALOX12 P18054 1/20 0.32
PDE5A O76074 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4D Q08499 1/20 0.31
MAPK14 Q16539 1/20 0.31
EPHX2 P34913 2/20 0.31
RXFP1 Q9HBX9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7497220 0.94 PARP10 (0.37) ALDH1A1HTTMAPTLMNAMEN1
SCHEMBL7494934 0.85 PARP10 (0.39) ALDH1A1HTTMAPTLMNAPARP10
SCHEMBL7464106 0.85 HIF1A (0.35) ALDH1A1MAPTMEN1KMT2A
SCHEMBL7466206 0.82 MAPK14 (0.36) LMNAMEN1KMT2AMAPK14EPHX2
SCHEMBL7470381 0.82 HTR2A (0.34) KMT2A
SCHEMBL8540310 0.82 HIF1A (0.37) ALDH1A1HTTMAPTLMNAMEN1
SCHEMBL7467539 0.79 MAOB (0.46) KMT2A
SCHEMBL8544631 0.79 MAPK14 (0.37) MAPTMAPK14RXFP1
SCHEMBL7467428 0.79 MAOB (0.43) ALDH1A1MAPT
SCHEMBL7503269 0.77 MAPT (0.38) ALDH1A1HTTMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865424-A1 PESTICIDES Novartis AG (CH) 1998-09-23 EP disclosed
WO-1997020809-A1 PESTICIDES NOVARTIS AG (CH) 1997-06-12 WO disclosed