Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540815 | 0.85 | FAAH (0.59) | FAAHHTR1ATRPV1HTR1DHTR1B | |
| SCHEMBL9268126 | 0.83 | KMT2A (0.49) | HTR1D | |
| SCHEMBL8544428 | 0.80 | ADRA2A (0.67) | — | |
| SCHEMBL8539238 | 0.80 | FAAH (0.51) | FAAHHTR1ATRPV1MTNR1AMTNR1B | |
| SCHEMBL9828299 | 0.80 | HTR1D (0.67) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL8540082 | 0.79 | HTR2A (0.53) | FAAHHTR1ATRPV1MTNR1AMTNR1B | |
| SCHEMBL9698973 | 0.79 | FAAH (0.57) | FAAHTRPV1MTNR1AMTNR1BTRPM8 | |
| SCHEMBL8557152 | 0.79 | MTNR1A (0.56) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL9697617 | 0.78 | HTR1D (0.57) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL23083090 | 0.77 | HTR1D (0.77) | HTR1AHTR1DHTR1BMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496222-B1 | Indole derivatives | MERCK PATENT GMBH (DE) | 1998-09-09 | — | — | EP | disclosed |
| EP-0496222-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |