SCHEMBL8542158

SCHEMBL8542158

O=C(NN1C(=O)CN=C(c2cnccn2)c2ccccc21)OCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
GRIN2B Q13224 1/20 0.39
SENP1 Q9P0U3 1/20 0.39
LMNA P02545 3/20 0.38
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
CCKBR P32239 2/20 0.37
CYP1A2 P05177 1/20 0.37
BRD4 O60885 2/20 0.37
BRD2 P25440 2/20 0.37
BRD3 Q15059 2/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7828642 0.86 HDAC3 (0.51) CYP3A4SENP1HDAC3HDAC1HDAC8
SCHEMBL8547679 0.83 GRIN2B (0.38) CYP3A4GRIN2BSENP1POLBHDAC3
SCHEMBL8549141 0.79 KDM4E (0.46) CCKBRCYP1A2SMN1; SMN2ALDH1A1
SCHEMBL8545456 0.79 SENP1 (0.42) SENP1HDAC3HDAC1HDAC8HDAC6
SCHEMBL8553126 0.74 MEN1 (0.42) SENP1POLBKMT2ASMN1; SMN2ALDH1A1
SCHEMBL8520160 0.71 RAB9A (0.42) CYP3A4CYP2D6CYP2C9POLBBRD4
SCHEMBL8548821 0.70 CYP1A2 (0.48) CYP3A4HDAC3HDAC1HDAC8HDAC6
SCHEMBL8606948 0.70 SENP1 (0.57) SENP1CCKBR
SCHEMBL8545459 0.70 SENP1 (0.57) SENP1CCKBR
SCHEMBL7423680 0.69 L3MBTL1 (0.52) LMNAPOLBSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0715624-B1 PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMA CO LTD (JP) 1998-04-08 EP disclosed
US-5728829-A MULTISTAGE REACTION OF N-PROTECTED BENZOTRIAZOLYL GLYCINE DERIVATIVE WITH AMINOKETONE, THEN REACTION WITH AMMONIA AND ACID CATALYZED CYCLIZATION FERRING-RESEARCH LIMITED (GB) 1998-03-17 US disclosed
WO-1995006040-A1 BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1995-03-02 WO disclosed