SCHEMBL8544280

SCHEMBL8544280

NC(=O)N(O)Cc1ccc(O[C@@H]2CCC[C@H](Oc3ccc(CN(O)C(N)=O)cc3)C2)cc1

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FURIN P09958 2/20 0.52
PARP10 Q53GL7 1/20 0.51
BCL2A1 Q16548 4/20 0.42
FFAR4 Q5NUL3 11/20 0.41
ALOX5 P09917 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8550341 0.77 FURIN (0.44) FURINPARP10FFAR4
SCHEMBL8546442 0.76 ALOX5 (0.51) PARP10ALOX5
SCHEMBL8545668 0.75 PARP10 (0.59) PARP10ALOX5
SCHEMBL16902888 0.75 FURIN (0.56) FURINPARP10FFAR4
SCHEMBL8550223 0.74 ALOX5 (0.56) ALOX5
SCHEMBL8550197 0.72 MMP2 (0.49) ALOX5
SCHEMBL8546020 0.72 FURIN (0.51) FURINPARP10FFAR4
SCHEMBL8546769 0.71 ITGB3 (0.49) ALOX5
SCHEMBL8545311 0.71 ITGB3 (0.49) ALOX5
SCHEMBL8549962 0.71 ITGB3 (0.49) ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed