Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 4/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27458015 | 0.85 | ATM (0.33) | ATMCACNA1GGRIN2BCCR3 | |
| SCHEMBL8544706 | 0.83 | GRIN2B (0.40) | GRIN2B | |
| SCHEMBL8543058 | 0.82 | CACNA1G (0.37) | ALDH1A2ATMCACNA1GMETAP2DRD2 | |
| SCHEMBL8547312 | 0.75 | MAOA (0.54) | DRD2DRD3GRIN1GRIN2B | |
| SCHEMBL8544708 | 0.72 | GRIN2B (0.45) | GRIN2BCCR3 | |
| SCHEMBL8545326 | 0.72 | GRIN2B (0.45) | GRIN2BCCR3 | |
| SCHEMBL8545330 | 0.72 | GRIN2B (0.45) | GRIN2BCCR3 | |
| SCHEMBL8541676 | 0.69 | GRIN2B (0.56) | ATMKCNH2GRIN2B | |
| SCHEMBL8540835 | 0.69 | GRIN2B (0.51) | DRD2GRIN1GRIN2B | |
| SCHEMBL27486618 | 0.68 | ALDH1A1 (0.36) | CACNA1GCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |