Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30213213 | 1.00 | KMT2A (0.66) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL6813422 | 0.87 | CA2 (0.63) | KMT2AHTTGAACA2CA5A | |
| Hydrochloric Acid SCHEMBL3647553 | 0.85 | CA2 (0.61) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL4067617 | 0.85 | KMT2A (0.60) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL8247534 | 0.84 | VCAM1 (0.59) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL4589706 | 0.83 | SMN1; SMN2 (0.63) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL6534914 | 0.83 | KMT2A (0.57) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL14574198 | 0.82 | MAPT (0.57) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL8099347 | 0.80 | KMT2A (0.72) | KMT2AHTTGAACA2CA5A | |
| SCHEMBL5899427 | 0.80 | KMT2A (0.72) | KMT2AHTTGAACA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174259-A | Modulators of intracellular chloride concentration | 意大利学院科技基金会 | 2022-03-11 | — | — | CN | claimed |
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | claimed |
| WO-2020202072-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2020-10-08 | — | — | WO | claimed |
| CN-101328150-A | New benzimidazole derivatives | ASTRAZENECA AB (SE) | 2008-12-24 | — | — | CN | claimed |
| CN-100413849-C | Benzimidazole derivatives | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | CN | claimed |
| CN-1784387-A | Novel benzimidazole derivatives | ASTRAZENECA AB (SE) | 2006-06-07 | — | — | CN | claimed |
| CN-114072390-B | RAD51 inhibitors | 赛泰尔治疗公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-117561262-A | Macrocyclic TAK1 inhibitors | 阿奎利恩有限公司 | 2024-02-13 | — | — | CN | disclosed |
| US-20230174507-A1 | IMIDAZOLE 3-OXIDE DERIVATIVE BASED ACSS2 INHIBITORS AND METHODS OF USE THEREOF | METABOMED LTD. (IL) | 2023-06-08 | — | — | US | disclosed |
| EP-4149928-A1 | IMIDAZOLE 3-OXIDE DERIVATIVE BASED ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2023-03-22 | — | — | EP | disclosed |
| CN-115697974-A | Imidazole 3-oxide derivative based ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-114174259-A | Modulators of intracellular chloride concentration | 意大利学院科技基金会 | 2022-03-11 | — | — | CN | disclosed |
| EP-3947345-A1 | MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION | Fondazione Istituto Italiano di Tecnologia (IT) | 2022-02-09 | — | — | EP | disclosed |
| CN-1356977-A | Glucagon antagonists/inverse agonists | NOVO NORDISK AS (DK) | 2002-07-03 | — | — | CN | disclosed |
| US-6291470-B1 | DELTA-OPIOID ANTAGONIST HAVING HIGH SELECTIVITY AND ACTIVITY, THAT EXHIBITS IMMUNOSUPPRESSIVE ACTION, ANTIALLERGIC ACTION, ANTI-INFLAMMATORY ACTION AND BRAIN CELL-PROTECTING ACTION | TORAY INDUSTRIES, INC. (JP) | 2001-09-18 | — | — | US | disclosed |
| US-6087369-A | AN IMMUNOSUPPRESSIVE AGENT, ANTIALLERGIC AGENT, ANTI-INFLAMMATORY AGENT AND BRAIN CELL-PROTECTING AGENT | TORAY INDUSTRIES, LTD. (JP) | 2000-07-11 | — | — | US | disclosed |
| CN-1043766-C | Indole derivative and preparation and pharmaceutical using of same | TORAY INDUSTRIES (JP) | 1999-06-23 | — | — | CN | disclosed |
| US-5852030-A | Indole derivatives, process for producing the same and medicinal uses of the same | TORAY INDUSTRIES, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| CN-1092425-A | Indole derivatives, its manufacture method and medicinal use thereof | TORAY INDUSTRIES (JP) | 1994-09-21 | — | — | CN | disclosed |
| EP-0614898-A1 | INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1994-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174507-A1 | IMIDAZOLE 3-OXIDE DERIVATIVE BASED ACSS2 INHIBITORS AND METHODS OF USE THEREOF | ACSS2, ADSS2, GLS2 | KMT2A 821/4885HTT 4781/4885GAA 2372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.