SCHEMBL8549303

SCHEMBL8549303

COc1ccc2[nH]cc(CC(N)CC(C)=O)c2c1Cl

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.41
MTNR1B P49286 4/20 0.41
NQO2 P16083 1/20 0.41
HTR2A P28223 4/20 0.41
IDO1 P14902 1/20 0.40
HTR1A P08908 2/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549306 0.82 HTR2A (0.39) MTNR1AMTNR1BNQO2HTR2AHTR1A
Oxalic Acid SCHEMBL8549166 0.76 HTR2A (0.56) MTNR1AMTNR1BNQO2HTR2AHTR1A
SCHEMBL8545111 0.75 MTNR1A (0.53) MTNR1AMTNR1BNQO2HTR2AHTR1A
SCHEMBL2541508 0.74 HTR2A (0.65) HTR2AHTR1AHTR2CHTR2B
Fumaric Acid SCHEMBL8549914 0.73 HTR2A (0.53) MTNR1AMTNR1BNQO2HTR2AHTR1A
Fumaric Acid SCHEMBL8549920 0.73 HTR2A (0.53) MTNR1AMTNR1BNQO2HTR2AHTR1A
SCHEMBL17417733 0.72 PRKAG1 (0.51) MTNR1AMTNR1BNQO2
SCHEMBL8546408 0.71 HTR1A (0.52) MTNR1AMTNR1BHTR2AIDO1HTR1A
SCHEMBL8545108 0.71 MTNR1A (0.55) MTNR1AMTNR1BNQO2HTR2B
SCHEMBL8544722 0.70 HTR2A (0.53) MTNR1AMTNR1BNQO2HTR2AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed