Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545353 | 0.85 | KDM4E (0.45) | LMNASMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL8550467 | 0.84 | CYP1A2 (0.50) | TRPM8SMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL8543410 | 0.83 | TRPM8 (0.42) | LMNATRPM8SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8550254 | 0.82 | TRPM8 (0.46) | LMNATRPM8SMN1; SMN2NPC1PKM | |
| SCHEMBL9035936 | 0.81 | ALDH1A1 (0.46) | LMNATRPM8SMN1; SMN2NPC1PKM | |
| SCHEMBL8666788 | 0.81 | TRPM8 (0.41) | LMNATRPM8SMN1; SMN2NPC1PKM | |
| SCHEMBL8544938 | 0.81 | ALDH1A1 (0.46) | LMNATRPM8RAB9AL3MBTL1MAPT | |
| SCHEMBL8545901 | 0.81 | ALDH1A1 (0.43) | TRPM8SMN1; SMN2L3MBTL1POLBMAPT | |
| SCHEMBL8548183 | 0.81 | SMN1; SMN2 (0.43) | LMNATRPM8SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8663140 | 0.80 | TRPM8 (0.46) | TRPM8SMN1; SMN2NPC1PKMNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |