SCHEMBL8545695

SCHEMBL8545695

COc1cc(Oc2ccc(C(N)O)cc2)cc(Oc2ccc(C(N)O)cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.44
LTA4H P09960 2/20 0.44
AOC3 Q16853 2/20 0.42
PARP10 Q53GL7 1/20 0.42
ALDH1A1 P00352 1/20 0.41
CYP2D6 P10635 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
ACACB O00763 1/20 0.40
ST14 Q9Y5Y6 2/20 0.40
ABL1 P00519 1/20 0.40
ABCB1 P08183 1/20 0.40
BCR P11274 1/20 0.40
ADRA2A P08913 1/20 0.40
ADRA1A P35348 1/20 0.40
MEN1 O00255 1/20 0.39
MAPK1 P28482 1/20 0.39
BLM P54132 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP1A1 P04798 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21585201 0.84 AOC3 (0.55) AOC3ALDH1A1CYP2D6CYP1A2CYP2C19
SCHEMBL8547791 0.81 CARM1 (0.43) SMN1; SMN2ALDH1A1CYP2D6CYP1A2CYP2C19
SCHEMBL8544288 0.81 ST14 (0.40) SMN1; SMN2ALDH1A1ST14MEN1KMT2A
SCHEMBL8545693 0.81 SLC2A1 (0.39) SMN1; SMN2AOC3ALDH1A1ST14MEN1
SCHEMBL29975972 0.74 LTA4H (0.58) LTA4HAOC3PARP10ALDH1A1MEN1
SCHEMBL25574740 0.74 LTA4H (0.58) LTA4HAOC3PARP10ALDH1A1MEN1
SCHEMBL756642 0.72 LTA4H (0.52) LTA4HAOC3PARP10ALDH1A1CYP2D6
SCHEMBL18383080 0.72 LTA4H (0.56) LTA4HAOC3PARP10ALDH1A1MEN1
SCHEMBL9488488 0.72 ALDH1A1 (0.79) SMN1; SMN2LTA4HALDH1A1CYP2D6CYP1A2
SCHEMBL15472280 0.71 NPBWR1 (0.43) SMN1; SMN2LTA4HALDH1A1ACACBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed