Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550890 | 0.88 | ATM (0.55) | KMT2AMEN1ALDH1A1MAPK1AR | |
| SCHEMBL8547192 | 0.78 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8548686 | 0.77 | LRRK2 (0.49) | KMT2AMEN1ALDH1A1MAPK1AR | |
| SCHEMBL8548608 | 0.76 | MAPT (0.44) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8549961 | 0.75 | MEN1 (0.44) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8548542 | 0.75 | ROCK2 (0.47) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL1786578 | 0.74 | ATM (0.73) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL10149747 | 0.71 | LMNA (0.64) | KMT2AMEN1ALDH1A1MAPK1AR | |
| SCHEMBL8552284 | 0.71 | PLAU (0.40) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL4065593 | 0.71 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |