SCHEMBL854814

SCHEMBL854814

CCCCOCCO[Si](C)(OCCOCCCC)OCCOCCCC

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.48
CYP3A4 P08684 3/20 0.46
MEN1 O00255 1/20 0.43
THRB P10828 1/20 0.43
HTT P42858 1/20 0.43
KMT2A Q03164 1/20 0.43
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.40
ADRB2 P07550 1/20 0.36
ADRB1 P08588 1/20 0.36
ADRB3 P13945 1/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 1/20 0.35
TDP1 Q9NUW8 1/20 0.33
RARB P10826 1/20 0.33
SPHK2 Q9NRA0 1/20 0.32
SPHK1 Q9NYA1 1/20 0.32
CES2 O00748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10893263 0.93 TSHR (0.43) TSHRCYP3A4MEN1THRBHTT
SCHEMBL10356609 0.89 TSHR (0.43) TSHRCYP3A4MEN1THRBHTT
SCHEMBL8607727 0.85 TSHR (0.48) TSHRCYP3A4MEN1THRBHTT
SCHEMBL93421 0.84 ADRB2 (0.43) TSHRCYP3A4THRBSMN1; SMN2ADRB2
SCHEMBL3963478 0.82 TSHR (0.50) TSHRCYP3A4MEN1THRBHTT
SCHEMBL1129112 0.82 TSHR (0.50) TSHRCYP3A4MEN1THRBHTT
SCHEMBL8636270 0.81 TSHR (0.67) TSHRCYP3A4MEN1THRBHTT
SCHEMBL988078 0.81 TSHR (0.67) TSHRCYP3A4MEN1THRBHTT
SCHEMBL1132722 0.81 TSHR (0.67) TSHRCYP3A4MEN1THRBHTT
SCHEMBL27130 0.81 TSHR (0.67) TSHRCYP3A4MEN1THRBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2476719-B1 IRREGULAR-SHAPED MICROPARTICLES, PROCESS FOR PRODUCTION OF IRREGULAR-SHAPED MICROPARTICLES, AND COSMETICS AND RESIN COMPOSITIONS CONTAINING IRREGULAR-SHAPED MICROPARTICLES TAKEMOTO OIL & FAT CO LTD (JP) 2019-01-02 EP disclosed
US-20170290762-A1 Method and Composition for Dag Mitigation on Hair INVENTION DEVELOPMENT MANAGEMENT COMPANY, LLC 2017-10-12 US disclosed
EP-2471841-B1 ORGANIC SILICONE PARTICLES, METHOD OF PRODUCING ORGANIC SILICONE PARTICLES, AND COSMETIC, RESIN COMPOSITION AND COATING COMPOSITION CONTAINING ORGANIC SILICONE PARTICLES TAKEMOTO OIL & FAT CO LTD (JP) 2014-07-30 EP disclosed
US-8524363-B2 Organosilicone fine particles of tetrahedral general shapes, method of production thereof and cosmetic materials, resin compositions and paint compositions containing same TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) 2013-09-03 US disclosed
EP-2433979-B1 IRREGULAR-SHAPED HOLLOW MICROPARTICLE, METHOD FOR PRODUCING SAME, AND COSMETIC MATERIAL AND RESIN COMPOSITION CONTAINING IRREGULAR-SHAPED HOLLOW MICROPARTICLE TAKEMOTO OIL & FAT CO LTD (JP) 2013-06-12 EP disclosed
US-20130090411-A1 RESIN COMPOSITIONS CONTAINING NON-SPERICAL HOLLOW FINE PARTICLES ARATANI SATOSHI (JP) 2013-04-11 US disclosed
US-20130001482-A1 METHOD OF PRODUCING OPTICAL DIFFUSIVE RESIN COMPOSITIONS AND OPTICAL DIFFUSIVE MOLDINGS SAITO CHIAKI (JP) 2013-01-03 US disclosed
EP-2476719-A1 IRREGULAR-SHAPED MICROPARTICLES, PROCESS FOR PRODUCTION OF IRREGULAR-SHAPED MICROPARTICLES, AND COSMETICS AND RESIN COMPOSITIONS CONTAINING IRREGULAR-SHAPED MICROPARTICLES Takemoto Yushi Kabushiki Kaisha (JP) 2012-07-18 EP disclosed
EP-2471841-A1 ORGANIC SILICONE PARTICLES, METHOD OF PRODUCING ORGANIC SILICONE PARTICLES, AND COSMETIC, RESIN COMPOSITION AND COATING COMPOSITION CONTAINING ORGANIC SILICONE PARTICLES Takemoto Yushi Kabushiki Kaisha (JP) 2012-07-04 EP disclosed
EP-2471872-A1 LIGHT-DIFFUSING RESIN COMPOSITION AND LIGHT-DIFFUSING MOLDED BODY Takemoto Yushi Kabushiki Kaisha (JP) 2012-07-04 EP disclosed
EP-2433979-A1 IRREGULAR-SHAPED HOLLOW MICROPARTICLE, METHOD FOR PRODUCING SAME, AND COSMETIC MATERIAL AND RESIN COMPOSITION CONTAINING IRREGULAR-SHAPED HOLLOW MICROPARTICLE Takemoto Yushi Kabushiki Kaisha (JP) 2012-03-28 EP disclosed
US-20110240936-A1 OPTICAL DIFFUSIVE RESIN COMPOSITIONS AND OPTICAL DIFFUSIVE MOLDINGS SAITO CHIAKI 2011-10-06 US disclosed
US-20110224308-A1 ORGANOSILICONE FINE PARTICLES, METHOD OF PRODUCTION THEREOF AND COSMETIC MATERIALS, RESIN COMPOSITIONS AND PAINT COMPOSITIONS CONTAINING SAME TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) 2011-09-15 US disclosed
US-20110171157-A1 NON-SPHERICAL FINE PARTICLES, METHOD OF PRODUCTION THEREOF AND COSMETIC MATERIALS AND RESIN COMPOSITIONS CONTAINING SAME ARATANI SATOSHI 2011-07-14 US disclosed
US-20110129672-A1 NON-SPHERICAL HOLLOW FINE PARTICLES, METHOD OF PRODUCTION THEREOF AND COSMETIC MATERIALS AND RESIN COMPOSITIONS CONTAINING SAME ARATANI SATOSHI 2011-06-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170290762-A1 Method and Composition for Dag Mitigation on Hair SGMS2, DAGLB, SGMS1 TSHR 4452/4885CYP3A4 3845/4885MEN1 1950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.