Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548264 | 0.86 | PKM (0.57) | NAMPTPKMMAPTGAAHTT | |
| SCHEMBL7334051 | 0.85 | MEN1 (0.54) | NAMPTPKMMAPTGAAHTT | |
| SCHEMBL8541545 | 0.81 | NAMPT (0.52) | NAMPTPKMMAPTGAAHTT | |
| SCHEMBL7334961 | 0.76 | MAPT (0.62) | NAMPTPKMMAPTGAAHTT | |
| SCHEMBL27336362 | 0.76 | GAA (0.52) | MAPTGAAHTTMEN1KMT2A | |
| SCHEMBL8545802 | 0.76 | F2 (0.75) | NAMPTPKMMAPTF2 | |
| SCHEMBL8547733 | 0.72 | MAPT (0.71) | NAMPTMAPTGAAHTTMEN1 | |
| SCHEMBL8549652 | 0.72 | ESR1 (0.66) | PKMMAPTGAAHTTMEN1 | |
| SCHEMBL20380302 | 0.72 | NAMPT (1.00) | NAMPTGAAHTT | |
| SCHEMBL7332305 | 0.70 | PGR (0.55) | MAPTGAAHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046710-C | New 4-aminopyridines, process for preparing the same and medicaments containing the same | LUOHE DIAGNOSTIC EQUIPMENT CO (DE) | 1999-11-24 | — | — | CN | disclosed |
| EP-0687253-B1 | 4-AMINOPYRIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS CONTAINING THE SAME | BOEHRINGER MANNHEIM GMBH (DE) | 1998-12-16 | — | — | EP | disclosed |
| CN-1119858-A | Aminopyridines, process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1996-04-03 | — | — | CN | disclosed |