SCHEMBL8549786

SCHEMBL8549786

C[CH][Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.33
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
MAPK1 P28482 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10679812 0.79 ALDH1A1 (0.34) MAPTESR1ESR2MAPK1ALDH1A1
SCHEMBL17798412 0.79 ALDH1A1 (0.33) MAPTESR1ESR2MAPK1ALDH1A1
SCHEMBL9242759 0.70 TSHR (0.32) TSHR
SCHEMBL9473201 0.70 ALDH1A1 (0.44) MAPTMAPK1ALDH1A1TSHRTDP1
SCHEMBL3526796 0.69 ESR1 (0.37) MAPTESR1ESR2MAPK1NR1H2
SCHEMBL20328588 0.69 ESR1 (0.37) MAPTESR1ESR2MAPK1NR1H2
SCHEMBL29749402 0.69 ESR1 (0.37) MAPTESR1ESR2MAPK1NR1H2
SCHEMBL3888384 0.69 ESR1 (0.37) MAPTESR1ESR2MAPK1NR1H2
SCHEMBL2595602 0.69 MAPT (0.38) MAPTESR1ESR2NR1H2NR1H3
SCHEMBL29102850 0.67 SMYD2 (0.34) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2668176-B1 A NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS SPHAERA PHARMA PTE LTD (SG) 2017-05-17 EP claimed
US-9428482-B2 Process for synthesis of polyphenols SPHAERA PHARMA PTE. LTD. (SG) 2016-08-30 US claimed
US-20140031421-A1 NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS SPHAERA PHARMA PTE. LTD. (SG) 2014-01-30 US claimed
CN-116783160-A Libraries of compounds 中外制药株式会社 2023-09-19 CN disclosed
US-20230101138-A1 POLYMER COMPOUND, METHOD FOR PRODUCING POLYMER COMPOUND, ADHESIVE COMPOSITION, CURED PRODUCT, METHOD FOR PRODUCING ADHESIVE COMPOSITION, AND METHOD FOR ADJUSTING ADHESION FORCE NATIONAL INSTITUTE FOR MATERIALS SCIENCE (JP) 2023-03-30 US disclosed
EP-4101870-A1 POLYMER COMPOUND, METHOD FOR PRODUCING POLYMER COMPOUND, ADHESIVE COMPOSITION, CURED PRODUCT, METHOD FOR PRODUCING ADHESIVE COMPOSITION, AND METHOD FOR ADJUSTING ADHESIVE STRENGTH National Institute for Materials Science (JP) 2022-12-14 EP disclosed
EP-2668176-B1 A NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS SPHAERA PHARMA PTE LTD (SG) 2017-05-17 EP disclosed
US-9556140-B2 Approach for synthesis of catechins SPHAERA PHARMA PVT. LTD. (IN) 2017-01-31 US disclosed
US-9428482-B2 Process for synthesis of polyphenols SPHAERA PHARMA PTE. LTD. (SG) 2016-08-30 US disclosed
US-20150368223-A1 NOVEL APPROACH FOR SYNTHESIS OF CATECHINS EPIRIUM BIO INC. 2015-12-24 US disclosed
US-20140031421-A1 NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS SPHAERA PHARMA PTE. LTD. (SG) 2014-01-30 US disclosed
EP-0714393-B1 THIAZOLES AS ANTIVIRAL PFIZER (US) 1998-09-23 EP disclosed
US-5789408-A Antiviral thiazoles PFIZER INC. (US) 1998-08-04 US disclosed
EP-0714393-A1 THIAZOLES AS ANTIVIRAL PFIZER INC. (US) 1996-06-05 EP disclosed
WO-1995005378-A1 ANTIVIRAL THIAZOLES PFIZER INC. (US) 1995-02-23 WO disclosed
US-5187286-A LEUKOTRIENE-B4 DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICAL AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 1993-02-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140031421-A1 NOVEL PROCESS FOR SYNTHESIS OF POLYPHENOLS COMT, NQO1, SPR MAPT 3090/4885ESR1 217/4885ESR2 592/4885
US-20150368223-A1 NOVEL APPROACH FOR SYNTHESIS OF CATECHINS NQO1, COMT, NNMT MAPT 3520/4885ESR1 261/4885ESR2 76/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.