Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formamide SCHEMBL8546773 | 0.76 | S1PR1 (0.47) | HDAC6SMN1; SMN2ADRA2A | |
| Formamide SCHEMBL8545827 | 0.75 | CARM1 (0.48) | THRBIDO1ALDH1A1CYP3A4TSHR | |
| Formamide SCHEMBL8546795 | 0.73 | SLC2A1 (0.39) | THRBIDO1HDAC1ALDH1A1HDAC8 | |
| SCHEMBL4941612 | 0.72 | THRB (0.56) | THRBIDO1NOS1NOS2ALDH1A1 | |
| SCHEMBL12976226 | 0.72 | THRB (0.56) | THRBIDO1NOS1NOS2HDAC6 | |
| Formamide SCHEMBL8545672 | 0.71 | PARP15 (0.51) | HPGD | |
| SCHEMBL8763263 | 0.70 | ADH1B (0.67) | ALDH1A1CYP3A4TSHRESR1ESR2 | |
| Diphenylmethane SCHEMBL28288286 | 0.69 | CALM1 (0.67) | HDAC6ALDH1A1HDAC8SMN1; SMN2KMT2A | |
| SCHEMBL17065246 | 0.69 | THRB (0.59) | THRBIDO1NOS1NOS2ALDH1A1 | |
| SCHEMBL6895044 | 0.69 | THRB (0.59) | THRBIDO1NOS1NOS2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696585-B1 | NOVEL BISOXADIAZOLIDINE DERIVATIVE | YAMANOUCHI PHARMA CO LTD (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5643931-A | ANTIDIABETIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0696585-A1 | NOVEL BISOXADIAZOLIDINE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |