Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45490 | 0.90 | LMNA (0.59) | LMNAGAATSHRCFTRALDH1A1 | |
| SCHEMBL10391427 | 0.81 | LMNA (0.45) | LMNAGAATSHRCFTRALDH1A1 | |
| SCHEMBL27706769 | 0.78 | BRD4 (0.47) | LMNATSHRCFTRALDH1A1HSD17B10 | |
| SCHEMBL10519876 | 0.76 | LMNA (0.58) | LMNAGAAL3MBTL1TDP1CNR2 | |
| SCHEMBL1405144 | 0.76 | LMNA (0.58) | LMNAGAAL3MBTL1TDP1CNR2 | |
| SCHEMBL5239843 | 0.76 | CTSS (0.51) | LMNAGAATSHRCFTRALDH1A1 | |
| SCHEMBL1508457 | 0.76 | LMNA (0.50) | LMNAGAATSHRL3MBTL1CFTR | |
| SCHEMBL726068 | 0.76 | TAS2R14 (0.54) | LMNAGAATSHRCFTRALDH1A1 | |
| SCHEMBL27570825 | 0.74 | LMNA (0.56) | LMNAGAAL3MBTL1TDP1CNR2 | |
| SCHEMBL11074677 | 0.74 | LMNA (0.56) | LMNAGAAL3MBTL1TDP1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |