Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 4/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543453 | 0.91 | CYP1A2 (0.50) | CYP1A2TRPM8MAPTALDH1A1HSD17B10 | |
| SCHEMBL8550254 | 0.91 | TRPM8 (0.46) | CYP1A2TRPM8MAPTALDH1A1HSD17B10 | |
| SCHEMBL8663140 | 0.91 | TRPM8 (0.46) | CYP1A2TRPM8MAPTALDH1A1MAPK1 | |
| SCHEMBL8549346 | 0.84 | LMNA (0.53) | CYP1A2TRPM8MAPTALDH1A1HSD17B10 | |
| SCHEMBL8549230 | 0.83 | TRPM8 (0.42) | CYP1A2TRPM8MAPTALDH1A1HSD17B10 | |
| SCHEMBL8551235 | 0.80 | ALDH1A1 (0.39) | CYP1A2TRPM8MAPTALDH1A1HSD17B10 | |
| SCHEMBL8591973 | 0.78 | ECE1 (0.42) | CYP1A2ALDH1A1POLBKDM4E | |
| SCHEMBL8544938 | 0.77 | ALDH1A1 (0.46) | TRPM8MAPTALDH1A1HSD17B10GAA | |
| SCHEMBL8666788 | 0.77 | TRPM8 (0.41) | TRPM8MAPTALDH1A1HSD17B10POLB | |
| SCHEMBL8545256 | 0.76 | TRPM8 (0.42) | TRPM8MAPTALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |