Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | UBE2M | P61081 | 3/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 8/20 | 0.35 |
| ▸ | HTR1B | P28222 | 8/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489144 | 0.82 | HTR1D (0.56) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8547695 | 0.82 | DRD2 (0.42) | DRD2SLC6A4NAMPT | |
| SCHEMBL8550182 | 0.81 | DRD2 (0.47) | DRD2SLC6A4UBE2MDCUN1D1HTR1D | |
| SCHEMBL8552510 | 0.80 | DRD2 (0.40) | DRD2SLC6A4NAMPTHTR1DHTR1B | |
| SCHEMBL8551516 | 0.80 | DRD2 (0.40) | DRD2SLC6A4UBE2MDCUN1D1HTR1A | |
| SCHEMBL8547871 | 0.79 | HTR1D (0.43) | DRD2HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8552124 | 0.79 | DRD2 (0.43) | DRD2SLC6A4NAMPTHTR1DHTR1A | |
| SCHEMBL8552507 | 0.79 | DRD2 (0.39) | DRD2SLC6A4HTR1DHTR1BNPY5R | |
| SCHEMBL8550474 | 0.78 | DRD2 (0.41) | DRD2SLC6A4NAMPTHTR1ACHRM4 | |
| SCHEMBL8552559 | 0.78 | DRD2 (0.47) | DRD2SLC6A4UBE2MDCUN1D1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |