Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 10/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490206 | 0.82 | HTR1D (0.65) | HTR1DHTR1BCHRM2DRD2HTR1A | |
| SCHEMBL8552657 | 0.81 | L3MBTL1 (0.49) | HTR1DHTR1BALDH1A1MAPTHTR1A | |
| SCHEMBL8552124 | 0.81 | DRD2 (0.43) | HTR1DDRD2ALDH1A1MAPTKDM4E | |
| SCHEMBL8550058 | 0.79 | DRD2 (0.41) | HTR1DHTR1BDRD2HTR1AHTR1F | |
| SCHEMBL8704937 | 0.77 | DRD2 (0.44) | DRD2ALDH1A1MAPTLMNATP53 | |
| SCHEMBL8552510 | 0.77 | DRD2 (0.40) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL8547605 | 0.76 | RORC (0.45) | HTR1DHTR1BCHRM2DRD2HTR1A | |
| SCHEMBL8552507 | 0.75 | DRD2 (0.39) | HTR1DHTR1BDRD2ALDH1A1MAPT | |
| SCHEMBL8551516 | 0.75 | DRD2 (0.40) | DRD2HTR1A | |
| SCHEMBL8548938 | 0.75 | HTR1D (0.63) | HTR1DACKR3HTR1BCHRM2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |